Analysis of news and views - from all fields of human interest across the globe - with a view to highlight and promote information useful for human enlightenment and development.
Saturday, October 25, 2025
Gold offers wealth protection not generation
Friday, October 3, 2025
Aging and illness are separable
Aging and illness are separable, said Manel Esteller MD PhD., the chairman of genetics at the University of Barcelona School of Medicine and senior author of a study published recently in Cell Reports Medicine.
Aging and Illness Are Separable: New Study Uncovers Secrets to Living to 117
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| Dr. Manel Esteller |
Born in San Francisco in 1907 and a resident of Catalonia, Spain, since age 8, Maria Branyas Morera lived a simple yet vibrant life, enjoying yogurt, gardening, walks, reading, playing the piano, and spending time with friends and dogs. Despite outliving Catalonia’s average female life expectancy of 86 years by over three decades, she remained in relatively good health until her passing. This remarkable longevity prompted scientists to explore what made her exceptional.
Led by Dr. Manel Esteller, chairman of genetics at the University of Barcelona School of Medicine, the research team, with Morera’s full cooperation, analyzed her biology at age 116. By collecting samples of her blood, urine, saliva, and stool, and documenting her lifestyle, they identified a unique combination of genetic, physiological, and environmental factors contributing to her long life.
Morera “won the genetics lottery”
The study found that Morera “won the genetics lottery,” as Dr. Esteller described. Her genome contained numerous variants linked to longevity, including those supporting DNA repair, clearing malfunctioning cells, controlling inflammation, and powering robust mitochondria. Researchers also discovered seven previously unidentified genetic variants likely critical to her extended lifespan. Notably, Morera lacked gene variants associated with major chronic diseases like cancer, Alzheimer’s, or diabetes, none of which she developed, with arthritis being her primary health concern.
Her immune system was exceptionally resilient, maintaining a robust supply of T cells that retained memories of past infections, including her survival as Spain’s oldest covid-19 patient. Unlike many elderly individuals, her immune system remained efficient, avoiding overactivity that could lead to autoimmune issues. Her gut microbiome further supported her health, rich with bacteria that produce anti-inflammatory substances, bolstering her immune system and overall well-being.
Morera’s lifestyle amplified her biological advantages. In her final decade, she consumed three plain yogurts daily and adhered to a Mediterranean diet rich in fish, olive oil, and fruit, eating lightly. She stayed active through walking and gardening until her later years and maintained healthy cholesterol and blood-sugar levels, resulting in a biological age 23 years younger than her chronological age. Socially, she engaged with residents at her assisted-living facility and welcomed visitors, fostering a sense of community.
Though Morera showed signs of aging, such as joint pain and elevated amyloid protein levels—a potential dementia marker—she never developed serious illnesses. As Dr. Esteller noted, “aging and illness are separable,” a key takeaway from her ability to delay disease until her peaceful passing in her sleep on August 19, 2024, at 117.
While the study focuses on a single individual, it underscores the interplay of genetics, immune function, microbiome health, and lifestyle in achieving extreme longevity. Dr. Nir Barzilai, founder of the Longevity Genes Project at Albert Einstein College of Medicine, emphasized the need for further research into supercentenarians to draw broader conclusions. Still, this study lays the groundwork for future discoveries about aging and potential interventions for healthier lives.
Dr. Esteller suggests that while Morera’s genetic advantages are unique, adopting aspects of her lifestyle—such as a balanced diet with yogurt, regular physical activity, and social engagement—could promote healthier aging. “Maybe try one yogurt a day,” he advised.
Maria Branyas Morera’s legacy continues to inspire scientists and those seeking a long, healthy life. For more information about the study, contact the University of Barcelona’s research office.
(Courtesy: Gretchen Reynolds Washington Post)
Thursday, August 21, 2025
Ukraine is basically Putin’s white whale. This is what he wants, and he’s not going to stop until he gets it, or until he’s convinced that he can’t get it”
"Ukraine is basically Putin’s white whale. This is what he wants, and he’s not going to stop until he gets it, or until he’s convinced that he can’t get it” said: Nate Reynolds, senior fellow at the Carnegie Endowment for International Peace and former Russia director at the National Security Council.
Nate Reynolds
Reynolds was quoted saying this in an analysis by Robyn Dixon and Catherine Belton published in today's Washington Post.
Friday, August 15, 2025
"Walk out of a meeting when it is obvious, you aren’t adding value. It’s not rude to leave, it’s rude to make someone stay and waste their time."
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| Elon Musk |
- Excessive meetings are the blight of big companies and almost always get worse over time. Please get of all large meetings, unless you're certain they are providing value to the whole audience, in which case keep them very short.
- Also get rid of frequent meetings, unless you are dealing with an extremely urgent matter. Meeting frequency should drop rapidly once the urgent matter is resolved.
- Walk out of a meeting or drop off a call as soon as it is obvious you aren't adding value. It is not rude to leave, it is rude to make someone stay and waste their time.
- Don't use acronyms or nonsense words for objects, software or processes at Tesla. In general, anything that requires an explanation inhibits communication. We don't want people to have to memorize a glossary just to function at Tesla.
- Communication should travel via the shortest path necessary to get the job done, not through the "chain of command". Any manager who attempts to enforce chain of command communication will soon find themselves working elsewhere.
- A major source of issues is poor communication between depts. The way to solve this is allow free flow of information between all levels. If, in order to get something done between depts, an individual contributor has to talk to their manager, who talks to a director, who talks to a VP, who talks to another VP, who talks to a director, who talks to a manager, who talks to someone doing the actual work, then super dumb things will happen. It must be ok for people to talk directly and just make the right thing happen.
- In general, always pick common sense as your guide. If following a "company rule" is obviously ridiculous in a particular situation, such that it would make for a great Dilbert cartoon, then the rule should change."
Thursday, August 14, 2025
"Of course, the US is not reliable, but it's indispensable."
"Of course, the US is not reliable, but it's indispensable," Said former Singapore diplomat Bilahari Kausikan during a a thought-provoking discussion during the 3rd India-Singapore Ministerial Roundtable (ISMR) in New Delhi on 13 August 2025.
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| Bilahari Kausikan |
Kausikan, who served as Singapore’s Permanent Representative to the United Nations from 1995 to 1998, highlighted India’s historical commitment to autonomy. He noted that India has cultivated a stronger relationship with the United States for strategic reasons but remains fundamentally self-reliant.
Addressing India’s complex relationship with China, Kausikan dismissed the notion that India’s tensions with Beijing are motivated by a desire to align with U.S. interests. Instead, he pointed to longstanding disputes in the Himalayas and a competitive dynamic encapsulated by the Chinese proverb, “One mountain can only have one tiger.”
Kausikan also contextualized India’s evolving relationship with the United States by reflecting on its historical alignment with the Soviet Union under successive governments following India’s first Prime Minister, Jawaharlal Nehru. While this alignment was strategically sound during the Cold War, the dissolution of the Soviet Union diminished Russia’s role as a counterbalance in global geopolitics. India’s continued relationship with Russia, though still significant, no longer offers the strategic leverage it once did, making closer ties with the U.S. a logical step. Kausikan described this shift as a pragmatic adaptation to a transformed global landscape.
Commenting on the reliability of the United States as a partner, Kausikan offered a candid assessment, stating, “Of course, the U.S. is not reliable, but it’s indispensable.” He pointed to the volatility of American politics, where shifts in administration every four years can upend policy continuity, even within the same political party. Despite this unpredictability, Kausikan stressed that the U.S. remains a critical global player, and countries like Singapore and India must find ways to work within this reality. He emphasized that neither Singapore nor India relies on the U.S. for direct defense. Instead, both nations look to the U.S. to maintain the broader balance of power in the region, driven by Washington’s own interests rather than as a favor to its partners.
Friday, August 8, 2025
The total cost of operations (TCO) of our chips is so good that even when the competitors' chips are free, it's not cheap enough.
Said Jensen Huang, CEO of NVIDIA Corporation, world's largest chip maker having a market cap of more than four trillions.
When asked, “Is it possible that you'll face competition?” Jensen Huang responded:
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| Jensen Huang |
Jensen Huang (born February 17, 1963, Tainan, Taiwan) is a Taiwanese-born American entrepreneur who cofounded the American semiconductor company NVIDIA Corporation. Under Huang’s leadership, NVIDIA has become one of the leading providers of graphics processing units (GPUs) and has taken center stage in the current artificial intelligence (AI) boom.
Monday, July 7, 2025
"When the richest man in the world wants to pick a fight with the most powerful man in the world, you know, it's not hard to see where the money's going to go"
In response to ongoing national conversation sparked by Elon Musk’s recent announcement of his “America Party,” veteran political analyst Joe offered commentary on the implications for the U.S. political landscape during an interview earlier this week.
“The idea of launching a third party because one feels excluded from Washington or has had a falling out with former allies strikes me as politically naïve,” Joe stated. “Elon Musk is a visionary—a generational genius with a profound impact on technology and business—but navigating the emotional terrain of American politics is an entirely different arena.”
Referencing the market's reaction following Musk’s announcement, Joe pointed out that Tesla’s stock experienced a sharp 7% drop, compounded by a report of a 14% decrease in second-quarter vehicle deliveries.
“This feels less like a political movement and more like a very public divorce,” Joe added. “Third parties have historically failed to gain traction in the U.S.—the system simply isn’t designed for them. It’s hard to view this latest development as anything but disruptive.”
He also emphasized the contrast in thinking between Elon Musk and Donald Trump.
“Musk is focused on the long game—Mars colonization, electric mobility, the debt ceiling decades from now. Trump, on the other hand, is thinking short-term. These are two men driven by radically different timelines and philosophies.”
Joe concluded his remarks with both caution and respect:
“There’s no doubt that Musk has changed the world. But politics is not just about logic—it’s about feelings, coalitions, and human unpredictability. That’s a dimension even the sharpest mind can struggle to calibrate.”
In lighter commentary, Joe ended the discussion with a nod to July 4th traditions and cultural quirks—highlighting competitive eater Joey Chestnut’s triumph in the Coney Island Hot Dog Eating Contest.
“Even in a divided America, we can still marvel at someone downing 70.5 hot dogs in 10 minutes,” he quipped.




